Aspartate-tRNA synthetase, type 2 (IPR004523)

Short name: Asp-tRNA_synthase_2

Overlapping homologous superfamilies


Family relationships


Aspartyl tRNA synthetase is an alpha2 dimer that belongs to class IIb. Structural analysis combined with mutagenesis and enzymology data on the yeast enzyme point to a tRNA binding process that starts by a recognition event between the tRNA anticodon loop and the synthetase anticodon binding module [PMID: 10873455].

This family represents a group of aspartyl-tRNA synthetases from the eukaryotic cytosol, from archaea and from some bacteria. In some species, this enzyme aminoacylates tRNA for both Asp and Asn; Asp-tRNA (asn) is subsequently transamidated to Asn-tRNA (asn).

GO terms

Biological Process

GO:0006422 aspartyl-tRNA aminoacylation

Molecular Function

GO:0005524 ATP binding
GO:0004815 aspartate-tRNA ligase activity
GO:0000166 nucleotide binding

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.