Sodium/potassium/calcium exchanger (IPR004481)

Short name: K/Na/Ca-exchanger

Overlapping homologous superfamilies


Family relationships


This entry represents the potassium-dependent sodium/calcium exchanger protein family (NCKX), also known as solute carrier family 24 (SLC24) [PMID: 23506883].

Five distinct gene products have been identified (NCKX 1-5) in animal tissues such as neurons, smooth muscle, skin pigment epithelium and in retinal rod and cone photoreceptors, indicating that NCKX proteins may play very specific roles, related to Ca2+ homeostasis [PMID: 18166528]. NCKX 1 and 2 are a critical components of the visual transduction cascade, controlling the calcium concentration of outer segments during light and darkness [PMID: 10608890, PMID: 10662833]. NCKX 5 probably transports 1 Ca2+ and 1 K+ in exchange for 4 Na+ and is involved in pigmentation, possibly by participating in ion transport in melanosomes [PMID: 16357253].

Drosophila Nckx30C may function in the removal and maintenance of calcium homeostasis during signaling in the adult and in signaling events during embryogenesis and patterning of imaginal disks [PMID: 10545508].

This entry also includes sodium/calcium exchangers from prokaryotes. MaX1 is a sodium/calcium exchanger from archaea that catalyses calcium uptake into membrane vesicles [PMID: 22287543].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.