Acetyl-CoA decarbonylase/synthase complex subunit alpha (IPR004460)

Short name: CDHA

Overlapping homologous superfamilies

Family relationships


Acetyl-CoA decarbonylase/synthase (ACDS) is a 5-subunit-containing multienzyme complex found exclusively in methanogens and certain other Archaea [PMID: 20202935]. ACDS catalyses the central reaction of acetyl C-C bond cleavage in methanogens growing on acetate and is also responsible for synthesis of acetyl units during growth on C-1 substrates [PMID: 12464601].

The ACDS complex contains five subunits, among which beta possesses an Ni-Fe-S active-site metal cluster, the A-cluster, at which reaction with acetyl-CoA takes place, generating an acetyl-enzyme species poised for C-C bond cleavage [PMID: 14664578]. The ACDS complex is made up of alpha, epsilon, beta, gamma and delta chains with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-(gamma(1)delta(1))(8).

GO terms

Biological Process

GO:0006084 acetyl-CoA metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.