Peptide chain release factor 1 (IPR004373)

Short name: PrfA

Overlapping homologous superfamilies


Family relationships



This entry represents peptide chain release factor 1 (PrfA, RF-1), and excludes the related peptide chain release factor 2 (PrfB, RF-2). RF-1 helps recognise and terminate translation at UAA and UAG stop codons [PMID: 4879404]. This entry also includes chloroplast release factor APG3, which is an orthologue of E. coli RF1 and is essential for chloroplast development. APG3 could complement E. coli RF1 mutants, but not RF2 mutants, indicating that AP3 may function as RF1 in E. coli, showing specificity of stop codon recognition [PMID: 17450416].

GO terms

Biological Process

GO:0006415 translational termination

Molecular Function

GO:0016149 translation release factor activity, codon specific

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.