FCP1 homology domain (IPR004274)

Short name: FCP1_dom

Overlapping homologous superfamilies

Domain relationships


Yeast FCP1 is an essential protein serine phosphatase (EC: that dephosphorylates the C-terminal domain (CTD) of RNA polymerase II. FCP1 orthologs are present in all known eukaryote proteomes. The N-terminal domain of FCP1 corresponds to the catalytic unit of the phosphatase and has been refered to as the FCP1 homology domain. The FCP1 homology domain, which is a ~180-residue module, is also found in many other proteins of unknown function. It contains a DxDx(T/V) motif preceded by four hydrophobic residues characteristic of a large family of metal-dependent phosphohydrolases and phosphotransferases. The first aspartate residue is likely to participate in catalysis, whereas the second could have a role in substrate recognition [PMID: 9405607, PMID: 10445027, PMID: 12556522, PMID: 10385623].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles