Bi-component toxin, staphylococci (IPR003963)

Short name: Bi-component_toxin_staph

Overlapping homologous superfamilies

Family relationships



Many virulence mechanisms are employed by Staphylococci to induce pathogenesis: these can include polysaccharide capsules and exotoxins [PMID: 9350200]. Examples of the latter are bi-component toxins, which involve the synergistic combination of an "S" and an "F" component. These undergo conformational changes in their protein structure and form oligomeric pores in the target cell membrane upon recognition of certain host receptors. The main cells targeted are polymorphonuclear cells, monocytes, erythrocytes and macrophages. Examples of this protein family include: leucocidin, gamma-hemolysin and alpha-hemolysin [PMID: 12636257, PMID: 8467905].

GO terms

Biological Process

GO:0009405 pathogenesis

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.