Domain
OAR domain (IPR003654)
Short name:
OAR_dom
Overlapping homologous superfamilies
None.
Domain relationships
None.
Description
This 14 amino acid motif has been identified within the C-terminal region of several paired-like homeodomain (HD) containing proteins [PMID: 8944018, PMID: 9466998]. It was named OAR domain after the initials of otp, aristaless, and rax [PMID: 9096350]. Although it has been proposed that this domain could be important for transactivation and be involved in protein-protein interactions or DNA binding [PMID: 9096350, PMID: 9140395], its function is not yet known. Some proteins known to contain a OAR domain include human RIEG, defects in which are the cause of Rieger syndrome [PMID: 8944018]; human OG12X and Mus musculus (Mouse) Og12x, whose function is not yet known [PMID: 9466998]; vertebrate Rax, which plays a role in the proliferation and/or differentiation of retinal cells [PMID: 9096350]; Drosophila DRX, which appears to be important in brain development [PMID: 9482887]; and human SHOX, encoded by the short stature homeobox-containing gene.
Semina EV, Reiter R, Leysens NJ, Alward WL, Small KW, Datson NA, Siegel-Bartelt J, Bierke-Nelson D, Bitoun P, Zabel BU, Carey JC, Murray JC.
Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome.
Nat. Genet. 14 392-9 1996
Semina EV, Reiter RS, Murray JC.
A new human homeobox gene OGI2X is a member of the most conserved homeobox gene family and is expressed during heart development in mouse.
Hum. Mol. Genet. 7 415-22 1998
Furukawa T, Kozak CA, Cepko CL.
rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina.
Proc. Natl. Acad. Sci. U.S.A. 94 3088-93 1997
Furukawa T, Kozak CA, Cepko CL.
rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina.
Proc. Natl. Acad. Sci. U.S.A. 94 3088-93 1997
Rao E, Weiss B, Fukami M, Rump A, Niesler B, Mertz A, Muroya K, Binder G, Kirsch S, Winkelmann M, Nordsiek G, Heinrich U, Breuning MH, Ranke MB, Rosenthal A, Ogata T, Rappold GA.
Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome.
Nat. Genet. 16 54-63 1997
Semina EV, Reiter R, Leysens NJ, Alward WL, Small KW, Datson NA, Siegel-Bartelt J, Bierke-Nelson D, Bitoun P, Zabel BU, Carey JC, Murray JC.
Cloning and characterization of a novel bicoid-related homeobox transcription factor gene, RIEG, involved in Rieger syndrome.
Nat. Genet. 14 392-9 1996
Semina EV, Reiter RS, Murray JC.
A new human homeobox gene OGI2X is a member of the most conserved homeobox gene family and is expressed during heart development in mouse.
Hum. Mol. Genet. 7 415-22 1998
Furukawa T, Kozak CA, Cepko CL.
rax, a novel paired-type homeobox gene, shows expression in the anterior neural fold and developing retina.
Proc. Natl. Acad. Sci. U.S.A. 94 3088-93 1997
Eggert T, Hauck B, Hildebrandt N, Gehring WJ, Walldorf U.
Isolation of a Drosophila homolog of the vertebrate homeobox gene Rx and its possible role in brain and eye development.
Proc. Natl. Acad. Sci. U.S.A. 95 2343-8 1998
InterPro