Knottin, scorpion toxin-like (IPR003614)

Short name: Scorpion_toxin-like

Overlapping homologous superfamilies

Domain relationships


Knottins are small proteins characterised by a cystine-knot [PMID: 18025039]. They constitute a large family of structurally related peptides with diverse biological functions, including inhibitors, anti-microbial peptides and toxins [PMID: 15551519].

The scorpion toxin-like domain is found in a subgroup of metazoan knottins mainly from the arthropoda, which include the antibacterial defensins [PMID: 8380707] and the scorpion alpha-neurotoxins [PMID: 12925796]. The plant sequences include members of the gamma-thionin family, which are plant defensins that have no antifungal activity. Other members are insect alpha-amylase inhibitors, cysteine-rich antifungal proteins and proteins annotated as proteinase inhibitors; those that are characterised belong to MEROPS inhibitor family I18, clan I.

GO terms

Biological Process

GO:0006952 defense response

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.