Interleukin-15/Interleukin-21 family (IPR003443)

Short name: IL-15/IL-21_fam

Overlapping homologous superfamilies

Family relationships


Interleukins (IL) are a group of cytokines that play an important role in the immune system. They modulate inflammation and immunity by regulating growth, mobility and differentiation of lymphoid and other cells.

Interleukin-15 (IL-15) has a variety of biological functions, including stimulation and maintenance of cellular immune responses [PMID: 10689297]. It is required for division of CD8+ T cells of memory phenotype, a process that is increased by inhibition of IL-2 [PMID: 10784451]. The numbers of CD8+ memory T cells in animals may, therefore, be controlled by a balance between IL-15 and -2.

This entry represents the interleukin-15 and interleukin-21 family.

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0005126 cytokine receptor binding

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.