Glial cell line-derived neurotrophic factor receptor (IPR003438)

Short name: GDNF_rcpt

Overlapping homologous superfamilies


Family relationships


Glial cell line-derived neurotrophic factor (GDNF) and its related factors neurturin (NTN), artemin (ART) and persephin (PSP), are members of the GDNF family of neurotrophic factors. They form a sub-group in the transforming growth factor-beta (TGF-beta) superfamily. These factors are involved in the promotion of neurone survival, exerting their effects through specific receptors.

The GDNF family receptors (GFRs) are glycosyl-phosphatidylinositol-linked, cell surface receptors [PMID: 10356294]. Four receptor subtypes, termed GFRalpha-1 to 4, are currently recognised. GFRalpha-1 and 2 are activated by GDNF and NTN respectively, although some degree of ligand promiscuity is thought to occur [PMID: 9192684]. Homologues for these receptor subtypes have been cloned from mammalian and avian tissue. The principal ligand for GFRalpha-3 is artemin. This receptor subtype is currently described only in mammals [PMID: 9576965]. GFRalpha-4 is activated by persephin and has so far only been found in chicken [PMID: 9647690]. This entry is general for types 1 to 3.

Activation of GFR family members triggers their interaction with the membrane-bound receptor kinase Ret. This induces Ret homo-dimerisation, triggering a cascade of intracellular signalling events such as the activation of the Ras-mitogen-activated protein kinase (MAPK), phosphoinositol-3-kinase (PI3K), Jun N-terminal kinase (JNK) and phospholipase C gamma (PLC gamma) dependent pathways [PMID: 10356294].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0038023 signaling receptor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.