Polysaccharide lyase family 8, central domain (IPR003159)

Short name: Lyase_8_central_dom

Overlapping homologous superfamilies

Domain relationships



Proteins containing this central domain consist of a group of secreted bacterial lyase enzymes capable of acting on a variety of substrates. One such enzyme is hyaluronate lyase, a Streptococcal surface enzyme that degrades hyaluronan and chondroitin, thereby helping to spread the bacteria throughout host tissues [PMID: 14523022]. Hyaluronate lyase (EC: is a four-domain enzyme containing an N-terminal carbohydrate-binding domain, a spacer domain, a catalytic domain, and a C-terminal domain that modulates access to the catalytic cleft of the enzyme. The central domain has a beta-sandwich topology, with 18 strands in two sheets. Other bacterial enzymes that display this structure include the central domain of chondroitin AC lyase (EC: [PMID: 10329169], the central domain of xanthan lyase (EC: [PMID: 12475987], and the third domain of chondroitin ABC lyase (EC: [PMID: 12706721]. This entry represents these domains of hyaluronate lyase, chondroitin AC lyase, xanthan lyase and chondroitin ABC lyase. This domain if almost always associated with the polysaccharide lyase family 8 C-terminal domain (IPR004103).

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016829 lyase activity

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.