Keratin, type I (IPR002957)

Short name: Keratin_I

Overlapping homologous superfamilies

Family relationships


Keratins are a well known group of intermediate filament proteins. Like actin filaments, keratins are flexible but provide a firm cell skeleton. Unlike actin, however, no known keratins are associated with motor functions. Approximately 10 keratins form the basis of hair or claw, with a further 20 found in internal body cavity epithelia. They are also found at desmosomes and hemi-desmosomes (cell/cell and cell/matrix contacts respectively). Type I keratins are a group of acidic intermediate filament proteins that exist as chains of hetero-dimers with basic type II keratins. Each type I keratin consists of head-, rod- and tail-like structures, the rod being constructed from three linked coils: 1A, 1B and 2. Type I proteins are associated with a number of inherited developmental disorders, such as baldness, beading of hair, and skin blistering.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005198 structural molecule activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.