Transcriptional regulator TACO1-like (IPR002876)

Short name: Transcrip_reg_TACO1-like

Overlapping homologous superfamilies

Family relationships


This is a family of transcriptional regulators. In mammals, TACO1 (Q9BSH4) activates the transcription of mitochondrially-encoded cytochrome c oxidase (COX1). Defects in TACO1 are a cause of Leigh syndrome (LS). LS is a severe neurological disorder characterised by bilaterally symmetrical necrotic lesions in subcortical brain regions that is commonly associated with systemic cytochrome c oxidase (COX) deficiency [PMID: 19503089]. In Pseudomonas aeruginosa, a member of this family, PmpR, is involved in regulation of the quinolone signal (PQS) system and of pyocyanine production. It negatively regulates the quorum-sensing response regulator pqsR of the PQS system by binding to its promoter region [PMID: 18641136].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.