Rotavirus non-structural protein NSP3 (IPR002873)

Short name: Rotavirus_NSP3

Overlapping homologous superfamilies

Domain relationships



This family consists of rotaviral non-structural RNA binding protein 34 (NS34 or NSP3). The NSP3 protein has been shown to bind viral RNA. The NSP3 protein consists of 3 conserved functional domains; a basic region which binds ssRNA, a region containing heptapeptide repeats mediating oligomerisation and a leucine zipper motif [PMID: 1326821]. NSP3 may play a central role in replication and assembly of genomic RNA structures [PMID: 1326821]. Rotaviruses have a dsRNA genome and are a major cause cause of acute gastroenteritis in the young of many species [PMID: 7871749].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003723 RNA binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.