Ham1-like protein (IPR002637)

Short name: Ham1p-like

Overlapping homologous superfamilies

Family relationships


This family contains the Saccharomyces cerevisiae (Baker's yeast) HAM1 protein P47119 and other hypothetical archaeal, bacterial and Caenorhabditis elegans proteins. S. cerevisiae HAM1 was originally identified as a gene that protects against the mutagenic effects of the base analogue 6-N-hydroxylaminopurine (HAP) which can be a natural product of monooxygenase activity on adenine [PMID: 8789257, PMID: 9918490]. Subsequent studies demonstrated that HAM1 detoxifies abnormal pyrimidine as well as purine nucleotides [PMID: 17899088].

Similarly, a Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides such as XTP to XMP and ITP to IMP, but not the standard nucleotides, in the presence of Mg or Mn ions. The enzyme exists as a homodimer [PMID: 10404228].

GO terms

Biological Process

GO:0009143 nucleoside triphosphate catabolic process

Molecular Function

GO:0047429 nucleoside-triphosphate diphosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.