tRNA-guanine(15) transglycosylase-like (IPR002616)

Short name: tRNA_ribo_trans-like

Overlapping homologous superfamilies

Domain relationships



Queuine tRNA-ribosyltransferases, also known as tRNA-guanine transglycosylases (TGT) EC:, modify tRNAs for asparagine, aspartic acid, histidine and tyrosine with queuine at position 34 and with archaeosine at position 15 in archaeal tRNAs. In bacteria it catalyses the exchange of guanine-34 at the wobble position with 7-aminomethyl-7-deazaguanine (preQ1), and subsequently the addition of a cyclopentenediol moiety to 7-aminomethyl-7-deazaguanine-34 tRNA giving a hypermodified base queuine (Q) in the wobble position [PMID: 8654383, PMID: 8323579]. In eukaryotes, TGT catalyzes the irreversible exchange of guanine in the unmodified tRNA with free queuine. Eukaryotes cannot synthesize queuine de novo and must obtain it from the diet or gut flora [PMID: 11255023].

The structure of TGT consists of an irregular (beta/alpha)8 barrel, represented by this entry, and a C-terminal zinc-containing subdomain [PMID: 8654383].

GO terms

Biological Process

GO:0006400 tRNA modification

Molecular Function

GO:0016763 transferase activity, transferring pentosyl groups

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.