Keratin-associated protein (IPR002494)

Short name: KAP

Overlapping homologous superfamilies


Family relationships



Keratin-associated proteins (KAPs) are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments [PMID: 9524245, PMID: 2250030]. This entry also includes the high-sulfur and high-tyrosine keratins from sheep and goats.

In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins, which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins [PMID: 14962103]. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0045095 keratin filament

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.