Ferric-uptake regulator (IPR002481)

Short name: FUR

Overlapping homologous superfamilies

Family relationships



The Ferric uptake regulator (Fur) family includes metal ion uptake regulator proteins, which are responsible for controlling the intracellular concentration of iron in many bacteria. The Fur protein (a dimer having one Fe2+ coordinated per monomer) acts as an iron-responsive, DNA-binding repressor protein that binds to a 'Furbox' with the consensus sequence GATAATGATAATCATTATC in the promoter of iron-regulated genes. Under low-iron condition, the Fur protein is released from the promoter and transcription resumed [PMID: 8522528]. Some members sense metal ions other than Fe2+. For example, the zinc uptake regulator (Zur) responds to Zn2+ [PMID: 9680209], the manganese uptake regulator (Mur) responds to Mn2+, and the nickel uptake regulator (Nur) responds to Ni2+ [PMID: 18259067, PMID: 16553888]. Other members sense signals other than metal ions. For example, PerR, a metal-dependent sensor of hydrogen peroxide. PerR regulates DNA-binding activity through metal-based protein oxidation, and co-ordinates Mn2+ or Fe2+ at its regulatory site [PMID: 16925555]. Furs can also control zinc homeostasis and is the subject of research on the pathogenesis of mycobacteria [PMID: 18452427, PMID: 12581348]. Fur family proteins contain an N-terminal winged-helix DNA-binding domain followed by a dimerization domain; this entry spans both those domains [PMID: 16774589, PMID: 17216355, PMID: 18945213, PMID: 12581348, PMID: 11466300, PMID: 9765558, PMID: 7590316, PMID: 16489762, PMID: 8196544, PMID: 7798143, PMID: 7765895, PMID: 9503612, PMID: 7812114, PMID: 10387106, PMID: 12177338, PMID: 17213192, PMID: 9701813, PMID: 11931550, PMID: 15802252, PMID: 15802251, PMID: 9784364, PMID: 10400588, PMID: 2823881].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003700 DNA-binding transcription factor activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.