Lupus La protein (IPR002344)

Short name: Lupus_La

Overlapping homologous superfamilies

Family relationships


The La protein is a 47kDa polypeptide that often acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome patients [PMID: 15016896]. It occurs in both the nucleus and the cytoplasm, where it takes on different roles [PMID: 14636586]. In the nucleus, La facilitates the production of tRNAs, acting as a RNA polymerase III (RNAP III) transcription factor by binding to the U-rich 3'UTR of nascent transcripts, assisting in their folding and maturation [PMID: 15004549]. In the cytoplasm, La facilitates the translation of specific mRNAs, acting as a translation factor. As a RNA binding protein (RBP), La associates with subsets of mRNAs that contain a 5'-terminal oligopyrimidine (5'TOP) motif known to control protein synthesis. The binding of La to specific classes of RNA molecules regulates their downstream processing, protects them from endonuclease digestion, and organises their export from the nucleus [PMID: 14690589, PMID: 12086614, PMID: 12560814, PMID: 11416181].

GO terms

Biological Process

GO:0006396 RNA processing

Molecular Function

GO:0003723 RNA binding

Cellular Component

GO:0005634 nucleus
GO:1990904 ribonucleoprotein complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.