Interleukin-3 (IPR002183)

Short name: IL-3

Overlapping homologous superfamilies

Family relationships



Interleukin-3 (IL3) is a cytokine that regulates blood-cell production by controlling the production, differentiation and function of granulocytes and macrophages [PMID: 3497843, PMID: 2413359]. The protein, which exists in vivo as a monomer, is produced in activated T-cells and mast cells [PMID: 3497843, PMID: 2413359], and is activated by the cleavage of an N-terminal signal sequence [PMID: 2413359].

IL3 is produced by T-lymphocytes and T-lymphomas only after stimulation with antigens, mitogens, or chemical activators such as phorbol esters. However, IL3 is constitutively expressed in the myelomonocytic leukaemia cell line WEHI-3B [PMID: 2413359]. It is thought that the genetic change of the cell line to constitutive production of IL3 is the key event in development of this leukaemia [PMID: 2413359].

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

GO:0008083 growth factor activity
GO:0005135 interleukin-3 receptor binding

Cellular Component

GO:0005576 extracellular region

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.