Glycoprotein hormone receptor family (IPR002131)

Short name: Gphrmn_rcpt_fam

Overlapping homologous superfamilies


Family relationships


Glycoprotein hormones (or gonadotropins) are protein hormones, that includes the mammalian hormones follicle-stimulating hormone (FSH, also known as follitropin), luteinizing hormone (LH, also known as lutropin), thyroid-stimulating hormone (TSH, also known as thyrotropin) and human chorionic gonadotropin (hCG). These hormones are central to the complex endocrine system that regulates normal growth, sexual development, and reproductive function [PMID: 6177696]. The hormones FSH, LH and TSH are secreted by the anterior pituitary gland [PMID: 6267989, PMID: 1445230], while the choriogonadotropins are secreted by the placenta [PMID: 19171054].

Glycoprotein hormone receptors are members the rhodopsin-like G-protein coupled receptor (GPCR) family. They function as receptors for the pituitary hormones thyrotropin (TSH receptor), follitropin (FSH receptor) and lutropin (LH receptor). In mammals the LH receptor is also the receptor for the placental hormone, human chorionic gonadotropin (hCG), so is denominated as a lutropin-choriogonadotropic hormone receptor (LHCG receptor). The receptors share close sequence similarity, and are characterised by large extracellular domains believed to be involved in hormone binding via leucine-rich repeats (LRR) [PMID: 8747461].

This entry represents the glycoprotein hormone receptor family, which includes the follicle stimulating hormone receptor, lutropin-choriogonadotropic hormone receptor and the thyroid stimulating hormone receptor.

GO terms

Biological Process

GO:0007186 G protein-coupled receptor signaling pathway

Molecular Function

GO:0016500 protein-hormone receptor activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.