Mitochondrial carrier protein (IPR002067)

Short name: Mit_carrier

Overlapping homologous superfamilies

Family relationships


A variety of substrate carrier proteins that are involved in energy transfer are found in the inner mitochondrial membrane [PMID: 2158156, PMID: 8325039, PMID: 8140286, PMID: 8487299]. Such proteins include: ADP/ATP carrier protein (ADP/ATP translocase); 2-oxoglutarate/malate carrier protein; phosphate carrier protein; tricarboxylate transport protein (or citrate transport protein); Graves disease carrier protein; yeast mitochondrial proteins MRS3 and MRS4; yeast mitochondrial FAD carrier protein; and many others. This family also includes peroxisomal proteins like PMP34 [PMID: 11121399].

Sequence analysis of selected members of the carrier protein family has suggested the presence of six transmembrane (TM) domains, with varying degrees of sequence conservation and hydrophilicity [PMID: 8325039]. The TM regions, and adjacent hydrophilic loops, are more highly conserved than other regions of the proteins [PMID: 8325039]. All members of the family appear to consist of a tripartite structure, each of the repeated segments being about 100 residues in length [PMID: 8325039]. Each repeat contains two TM domains, the first being more hydrophobic, with conserved glycyl and prolyl residues. Five of the six TM domains are followed by the conserved sequence (D/E)-Hy(K/R), where - denotes any residue and Hy is a hydrophobic position [PMID: 8325039].

GO terms

Biological Process

GO:0055085 transmembrane transport

Molecular Function

GO:0022857 transmembrane transporter activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.