Asparagine synthase (IPR001962)

Short name: Asn_synthase

Overlapping homologous superfamilies


Domain relationships



Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B (EC: catalyses the assembly of asparagine from aspartate, Mg(2+)ATP, and glutamine. The three-dimensional architecture of the N-terminal domain of asparagine synthetase B is similar to that observed for glutamine phosphoribosylpyrophosphate amidotransferase while the molecular motif of the C-domain is reminiscent to that observed for GMP synthetase [PMID: 10587437].

Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine [PMID: 11551215]. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a synthetase domain. The N-terminal glutaminase domain hydrolyzes glutamine to glutamic acid and ammonia [PMID: 10587437].

GO terms

Biological Process

GO:0006529 asparagine biosynthetic process

Molecular Function

GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.