Membrane attack complex component/perforin/complement C9 (IPR001862)

Short name: MAC_perforin

Overlapping homologous superfamilies


Family relationships


Complement component C9 is a multi-domain protein that contains an N-terminal type-1 TSP domain, an LDL-receptor class A repeat, a number of potential transmembrane (TM) regions and a C-terminal EGF-like domain [PMID: 3219351, PMID: 4018030, PMID: 1722985]. Hydropathy analysis of the sequence indicates the N-terminal half of C9 to be predominantly hydrophilic in character, while the C-terminal section is more hydrophobic. The amphipathic organisation of the primary structure is consistent with the known potential of polymerised C9 to penetrate lipid bilayers, causing the formation of transmembrane channels [PMID: 1722985, PMID: 6095282]

GO terms

Biological Process

GO:0006955 immune response

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005579 membrane attack complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.