Glycoside hydrolase, family 34 (IPR001860)

Short name: Glyco_hydro_34

Overlapping homologous superfamilies

Family relationships



O-Glycosyl hydrolases (EC:3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

Glycoside hydrolase family 34 GH34 comprises enzymes with only one known activity; sialidase or neuraminidase EC:

Neuraminidases cleave the terminal sialic acid residues from carbohydrate chains in glycoproteins. Sialic acid is a negatively charged sugar associated with the protein and lipid portions of lipoproteins. In Influenza virus, neuraminidases prevent self-aggregation by removing the carbohydrate from the viral envelope thus facilitating the mobility of the virus to and from the site of infection. Antiviral agents that inhibit influenza viral neuraminidase activity are of major importance in the control of influenza [PMID: 10623375].

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0004308 exo-alpha-sialidase activity

Cellular Component

GO:0033644 host cell membrane
GO:0016020 membrane
GO:0055036 virion membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.