Adenosine kinase (IPR001805)

Short name: Adenokinase

Overlapping homologous superfamilies

Family relationships



Adenosine kinase (ADK) phosphorylates adenosine and other related nucleosides [PMID: 8577746, PMID: 8917457]. It is exclusive to eukaryotes [PMID: 9070863] and is a key enzyme in the purine salvage pathway. ADK catalyses the reaction:

Adenosine + ATP = ADP + AMP

This reaction prevents toxic levels of adenosine building up within the cell. Experiments have been carried out on Gallus gallus (chicken) embryonic neurons to document the toxicity of adenosine, and the associated requirement for ADK [PMID: 9654340].

Adenosine and ATP have been connected with pain, and the control of pain [PMID: 9650842]. Associated with this, adenosine has also been shown to have a number of anti-inflammatory activities. Human ADK bears little sequence similarity to other mammalian nucleoside kinases, but does share high similarity with some microbrial ribokinases and fructokinases, suggesting possible evolutionary connections [PMID: 8577746, PMID: 8917457].

GO terms

Biological Process

GO:0006166 purine ribonucleoside salvage

Molecular Function

GO:0004001 adenosine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.