Gdt1 family (IPR001727)

Short name: Gdt1

Overlapping homologous superfamilies


Family relationships



Budding yeast Gdt1 is a Golgi-localized calcium transporter required for stress-induced calcium signalling and protein glycosylation [PMID: 27075443]. Its human homologue, TMEM165, may be a Golgi Ca2(+)/H(+) antiporter [PMID: 24530912]. Defects in the human protein TMEM165 cause a subtype of Congenital Disorders of Glycosylation [PMID: 23569283]. In Arabidopsis , this protein is variously known as CCHA1 (a chloroplast-localized potential Ca(2+)/H(+) antiporter), chloroplastic PAM71 (photosynthesis affected mutant 71), and GDT1-like protein 1, chloroplastic. It has been reported to be a putative chloroplast-localized Ca(2+)/H(+) antiporter with critical functions in the regulation of PSII and in chloroplast Ca(2+) and pH homeostasis [PMID: 27302341]. It has also been suggested that it may function in Mn(2+) uptake into thylakoids, ensuring optimal PSII performance [PMID: 27020959].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns