Solute-binding protein family 3/N-terminal domain of MltF (IPR001638)

Short name: Solute-binding_3/MltF_N

Overlapping homologous superfamilies


Domain relationships


Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins [PMID: 8003968, PMID: 18310026].

On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped [PMID: 8336670] into eight families or clusters, which generally correlate with the nature of the solute bound.

This entry represents a domain found in the solute-binding protein family 3 members from Gram-positive bacteria, Gram-negative bacteria and archaea. This domain can also be found in the N-terminal of the membrane-bound lytic murein transglycosylase F (MltF) protein. MltF is a murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product [PMID: 18234673].

Familiy 3 members include:

  • Histidine-binding protein (gene hisJ) of Escherichia coli and related bacteria. An homologous lipoprotein exists in Neisseria gonorrhoeae.
  • Lysine/arginine/ornithine-binding proteins (LAO) (gene argT) of Escherichia coli and related bacteria are involved in the same transport system than hisJ. Both solute-binding proteins interact with a common membrane-bound receptor hisP of the binding protein dependent transport system HisQMP.
  • Glutamine-binding proteins (gene glnH) of Escherichia coli and Bacillus stearothermophilus.
  • Glutamate-binding protein (gene gluB) of Corynebacterium glutamicum.
  • Arginine-binding proteins artI and artJ of Escherichia coli.
  • Nopaline-binding protein (gene nocT) from Agrobacterium tumefaciens.
  • Octopine-binding protein (gene occT) from Agrobacterium tumefaciens.
  • Major cell-binding factor (CBF1) (gene: peb1A) from Campylobacter jejuni.
  • Bacteroides nodosus protein aabA.
  • Cyclohexadienyl/arogenate dehydratase of Pseudomonas aeruginosa, a periplasmic enzyme which forms an alternative pathway for phenylalanine biosynthesis.
  • Escherichia coli protein fliY.
  • Vibrio harveyi protein patH.
  • Escherichia coli hypothetical protein ydhW.
  • Bacillus subtilis hypothetical protein yckB.
  • Bacillus subtilis hypothetical protein yckK.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.