DNA/RNA non-specific endonuclease (IPR001604)

Short name: DNA/RNA_non-sp_Endonuclease

Overlapping homologous superfamilies


Domain relationships


A family of bacterial and eukaryotic endonucleases EC:3.1.30 share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. A histidine has been shown [PMID: 8078761] to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0003676 nucleic acid binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.