Transaldolase/Fructose-6-phosphate aldolase (IPR001585)

Short name: TAL/FSA

Overlapping homologous superfamilies

Family relationships


Transaldolase (TAL) is an enzyme of the pentose phosphate pathway (PPP) found almost ubiquitously in the three domains of life (Archaea, Bacteria, and Eukarya). TAL shares a high degree of structural similarity and sequence identity with fructose-6-phosphate aldolase (FSA) [PMID: 11120740]. They both belong to the class I aldolase family [PMID: 26131847]. Their protein structures have been revealed [PMID: 25267444].

Transaldolase (EC: catalyses the reversible transfer of a three-carbon ketol unit from sedoheptulose 7-phosphate to glyceraldehyde 3-phosphate to form erythrose 4-phosphate and fructose 6-phosphate. This enzyme, together with transketolase, provides a link between the glycolytic and pentose-phosphate pathways. Transaldolase is an enzyme of about 34 kDa whose sequence has been well conserved throughout evolution. A lysine has been implicated [PMID: 8109173] in the catalytic mechanism of the enzyme; it acts as a nucleophilic group that attacks the carbonyl group of fructose-6-phosphate.

Fructose-6-phosphate aldolase was originally thought to be transaldolases or transaldolase-related proteins. However, they perform a novel reaction, the cleavage or formation of fructose 6-phosphate [PMID: 11120740].

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.