Binding Site

Copper centre Cu(A) (IPR001505)

Short name: Copper_CuA


The Cu(A) centre contains a mixed valence binuclear copper binding site formed of about 50 amino acids containing two cysteines and histidines and one glutamate and methionine [PMID: 7592701]. The Cu(A) centre has been identified in subunit II of cytochrome c oxidase and nitrous oxide reductase [PMID: 1324168, PMID: 1324835].

Cytochrome c oxidase (EC: [PMID: 6307356, PMID: 8083153] is an oligomeric enzymatic complex which is a component of the respiratory chain and is involved in the transfer of electrons from cytochrome c to oxygen. In eukaryotes this enzyme complex is located in the mitochondrial inner membrane; in aerobic prokaryotes it is found in the plasma membrane. The enzyme complex consists of 3-4 subunits (prokaryotes) to up to 13 polypeptides (mammals). Subunit II (see IPR011759, IPR002429) transfers the electrons from cytochrome c to the catalytic subunit I. It provides the substrate-binding site and contains a Cu(A) centre that is probably the primary acceptor in cytochrome c oxidase.

Nitrous oxide reductase (EC: (gene nosZ) of Pseudomonas is part of the bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide. NosZ is a periplasmic homodimer that contains a dinuclear copper centre, probably located in a 3-dimensional fold similar to the cupredoxin-like fold that has been suggested for the copper-binding site of subunit II [PMID: 1324168].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005507 copper ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns