Glycoside hydrolase family 47 (IPR001382)

Short name: Glyco_hydro_47

Overlapping homologous superfamilies

Family relationships



O-Glycosyl hydrolases (EC:3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [PMID: 7624375, PMID: 8535779]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

Glycoside hydrolase family 47 GH47 comprises enzymes with only one known activity; alpha-mannosidase (EC:

Alpha-mannosidase is involved in the maturation of Asn-linked oligo-saccharides [PMID: 8144580]. The enzyme hydrolyses terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide man(9)(glcnac)(2) in a calcium-dependent manner. The mannose residues are trimmed away to produce, first, man(8)glcnac(2), then a man(5)(glcnac)(2) structure.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005509 calcium ion binding
GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.