Cysteine-rich secretory protein-related (IPR001283)

Short name: CRISP-related

Overlapping homologous superfamilies

Family relationships


The cysteine-rich secretory proteins (Crisp) are predominantly found in the mammalian male reproductive tract as well as in the venom of reptiles. This family includes mammalian testis-specific protein (Tpx-1), also known as cysteine-rich secretory protein 2 (CRISP2) [PMID: 2613236]; venom allergen 5 from vespid wasps and venom allergen 3 from fire ants, which are potent allergens that mediate allergic reactions to stings insects of the Hymenoptera family [PMID: 8454859]; plant pathogenesis proteins of the PR-1 family [PMID: 2026137], which are synthesised during pathogen infection or other stress-related responses; allurin, a sperm chemoattractant [PMID: 18342304], serotriflin [PMID: 18222185], etc.

The precise function of some of these proteins is still unclear. Tpx-1 or CRISP2 may regulate some ion channels' activity and thereby regulate calcium fluxes during sperm capacitation [PMID: 16339766].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.