2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IPR001228)

Short name: IspD

Overlapping homologous superfamilies

Family relationships


2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase (IspD) catalyses the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) in the deoxyxylulose pathway of isopentenyl diphosphate (IPP) biosynthesis [PMID: 10841550]. This mevalonate independent pathway that utilizes pyruvate and glyceraldehydes 3-phosphate as starting materials for production of IPP occurs in a variety of bacteria, archaea and plant cells, but is absent in mammals. The isoprenoid pathway is a well known target for anti-infective drug development [PMID: 17081012, PMID: 17921290]. In about twenty percent of bacterial genomes, this protein occurs as IspDF, a bifunctional fusion protein.

GO terms

Biological Process

GO:0008299 isoprenoid biosynthetic process

Molecular Function

GO:0050518 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.