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Overview
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Pathways & interactions
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Cross-references
Domain
TGF-beta, propeptide (IPR001111)
Short name: TGF-b_propeptide
Overlapping homologous superfamilies
None.
Domain relationships
None.
Description
TGF-beta is secreted as a latent complex, consisting of the TGF-beta dimer non-covalently bound to LAP (latency associated peptide) plus a latent TGF-beta binding protein (LTBP). After post-translational processing, TGF-beta binds non-covalently to LAP, a homodimer formed from the propeptide region of TGF-beta, to confer latency [PMID: 9150447]. Latent TGF-beta can then be targeted to the extracellular matrix (ECM) by LTBP. The LAP dimer is usually disulfide-bound to LTBP [PMID: 15611103].
This entry represents the propeptide region of TGF-beta that forms LAP.
Contributing signatures
Signatures from InterPro member databases are used to construct an entry.
Pfam
- PF00688 (TGFb_propeptide)