Domain

TGF-beta, propeptide (IPR001111)

Short name: TGF-b_propeptide

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

TGF-beta is secreted as a latent complex, consisting of the TGF-beta dimer non-covalently bound to LAP (latency associated peptide) plus a latent TGF-beta binding protein (LTBP). After post-translational processing, TGF-beta binds non-covalently to LAP, a homodimer formed from the propeptide region of TGF-beta, to confer latency [PMID: 9150447]. Latent TGF-beta can then be targeted to the extracellular matrix (ECM) by LTBP. The LAP dimer is usually disulfide-bound to LTBP [PMID: 15611103].

This entry represents the propeptide region of TGF-beta that forms LAP.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam