Bromo adjacent homology (BAH) domain (IPR001025)

Short name: BAH_dom

Overlapping homologous superfamilies


Domain relationships



The BAH (bromo-adjacent homology) is commonly found in chromatin-associated proteins [PMID: 23907388]. It is found in proteins such as eukaryotic DNA (cytosine-5) methyltransferases IPR001525, the origin recognition complex 1 (Orc1) proteins, as well as several proteins involved in transcriptional regulation. The BAH domain appears to act as a protein-protein interaction module specialised in gene silencing, as suggested for example by its interaction within yeast Orc1p with the silent information regulator Sir1p. The BAH module might therefore play an important role by linking DNA methylation, replication and transcriptional regulation [PMID: 10100640].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003682 chromatin binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles