Interleukin-1 family (IPR000975)

Short name: IL-1_fam

Overlapping homologous superfamilies

Family relationships


Interleukin-1 alpha and interleukin-1 beta (IL-1 alpha and IL-1 beta) are cytokines that participate in the regulation of immune responses, inflammatory reactions, and hematopoiesis [PMID: 2969618]. Two types of IL-1 receptor, each with three extracellular immunoglobulin (Ig)-like domains, limited sequence similarity (28%) and different pharmacological characteristics have been cloned from mouse and human cell lines: these have been termed type I and type II receptors [PMID: 8702856]. The receptors both exist in transmembrane (TM) and soluble forms: the soluble IL-1 receptor is thought to be post-translationally derived from cleavage of the extracellular portion of the membrane receptors. The receptors can both bind all three forms of IL-1: IL-1 alpha, IL-1 beta and the receptor antagonist IL-1RA [PMID: 1833184].

This entry represents the Interleukin-1 family, which includes seven ligands with agonist activity (IL1-alpha and IL1-beta, IL-18, IL-33, IL36-alpha, IL36-beta, IL36-gamma), three receptor antagonists (IL-1Ra, IL-36Ra, IL-38), and an anti-inflammatory cytokine (IL-37) [PMID: 24332029].

GO terms

Biological Process

GO:0006955 immune response
GO:0006954 inflammatory response

Molecular Function

GO:0005125 cytokine activity

Cellular Component

GO:0005615 extracellular space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.