ZU5 domain (IPR000906)

Short name: ZU5_dom

Overlapping homologous superfamilies


Domain relationships



The ZU5 domain is a domain of 90-110 residues present in zona occludens 1 (ZO-1) protein, in unc5-like netrin receptors and in ankyrins. The ZU5 domain is named after the mouse tight junction protein ZO-1 and the C. elegans uncoordinated protein 5 (unc-5) and related Unc5-like netrin receptors. ZU5 domains are found in eukaryotic proteins that in most cases contain a C-terminal death domain. Other domains which can be found N-terminal to a ZU5 domain are ankyrin repeats; Ig-like and TSP1 repeats; PDZ, SH3 and guanylate kinase; or leucine-rich repeats (LRR) [PMID: 9126742, PMID: 9126743, PMID: 14769797, PMID: 15073321]. The ZU5 domain can function as a spectrin-binding domain in ankyrins [PMID: 15262991], and participates in induction of apoptosis and binding of melanoma-associated antigen D1 (MAGE-D1/NRAGE) in UNC5H1-3 [PMID: 12598531].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles