Gcp-like domain (IPR000905)

Short name: Gcp-like_dom

Overlapping homologous superfamilies


Domain relationships



This domain was identified in proteins including Kae1 and Gcp (YgjD), which were originally thought to be endopeptidases belonging to the peptidase M22 family [PMID: 1885539]. However, there is a lack of experimental evidence to support peptidase activity as a general property, and this has not been confirmed in other orthologues [PMID: 17766251, PMID: 21183954]. Recent research indicates that the Kae1 and Gcp proteins are involved in the biosynthesis of N6-threonylcarbamoyl adenosine, a universal modification found at position 37 of tRNAs that read codons beginning with adenine [PMID: 21285948]. This domain is also present in Bacillus subtilis YdiC and Escherichia coli YeaZ. These proteins have been recently renamed as TsaB, and have also been shown to be involved in N6-Threonylcarbamoylad enonsine (t(6)A) biosynthesis [PMID: 23072323, PMID: 22378793].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.