Pathways & interactions
AP-1 transcription factor (IPR000837)
Short name: AP-1
Overlapping homologous superfamilies
- AP-1 transcription factor (IPR000837)
- Basic leucine zipper transcriptional factor ATF-like (IPR029820)
- Basic leucine zipper transcriptional factor ATF-like 3 (IPR029818)
- Fos-related antigen 1 (IPR029815)
- Fos-related antigen 2 (IPR029814)
- Jun dimerization protein 2 (IPR029819)
- Protein FosB (IPR029813)
- c-Fos/v-Fos (IPR029816)
- cAMP-dependent transcription factor ATF-3 (IPR029812)
The transcription factor activator protein (AP)-1 consists of Jun (c-Jun, JunB, and JunD), Fos (c-Fos, FosB, Fra1, and Fra2), ATF and JDP family members [PMID: 15564374]. They are basic leucine zipper transcription factors that play a central role in regulating gene transcription in various biological processes [PMID: 12424143]. This entry includes Fos, ATF-3 and JDP family members.
AP-1 proteins have a alpha-helical bZIP domain, which contains a basic DNA-binding region and regularly spaced leucine residues known as the leucine zipper motif [PMID: 23787991]. They have similar protein structure and can either form homodimers or form heterodimers with other AP-1 proteins (predominantly with Jun proteins), which can then bind to TRE-like sequences (consensus sequence 5'-TGAG/CTCA-3') [PMID: 15564374]. Each of these proteins are expressed in different tissues and can be regulated in different ways, which means that every cell type has a complex mixture of AP-1 dimers with subtly different functions [PMID: 15564374].