Phosphoribosyltransferase domain (IPR000836)

Short name: PRibTrfase_dom

Overlapping homologous superfamilies

Domain relationships


This entry refers to the phosphoribosyl transferase (PRT) type I domain. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrpphosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. This domain is found in a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:, hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:, ribose-phosphate pyrophosphokinase EC:, amidophosphoribosyltransferase EC:, orotate phosphoribosyltransferase EC:, uracil phosphoribosyltransferase EC:, and xanthine-guanine phosphoribosyltransferase EC: In Arabidopsis, at the very N terminus of this domain is the P-Loop NTPase domain [PMID: 17143579, PMID: 11751055, PMID: 18550080, PMID: 15689504, PMID: 18399692, PMID: 12808089, PMID: 8894695, PMID: 22075667, PMID: 15096496, PMID: 7030616, PMID: 6105839, PMID: 21366534, PMID: 18535147].

GO terms

Biological Process

GO:0009116 nucleoside metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.