Triacylglycerol lipase family (IPR000734)

Short name: TAG_lipase

Overlapping homologous superfamilies

Family relationships


Triglyceride lipases (EC: are lipolytic enzymes that hydrolyse ester linkages of triglycerides [PMID: 3147715]. Lipases are widely distributed in animals, plants and prokaryotes. At least three tissue-specific isozymes exist in higher vertebrates, pancreatic, hepatic and gastric/lingual. These lipases are closely related to each other and to lipoprotein lipase (EC:, which hydrolyses triglycerides of chylomicrons and very low density lipoproteins (VLDL) [PMID: 2917565].

The most conserved region in all these proteins is centred around a serine residue which has been shown [PMID: 2304545] to participate, with an histidine and an aspartic acid residue, in a charge relay system. Such a region is also present in lipases of prokaryotic origin and in lecithin-cholesterol acyltransferase (EC: (LCAT) [PMID: 3458198], which catalyses fatty acid transfer between phosphatidylcholine and cholesterol.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0052689 carboxylic ester hydrolase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.