RIH domain (IPR000699)

Short name: RIH_dom

Overlapping homologous superfamilies

Domain relationships



Ryanodine (RyR) and Inositol 1,4,5-trisphosphate (IP3) receptors are intracellular Ca2+-release channels. The RIH (RyR and IP3R Homology) domain is an extracellular domain from these two types of calcium channels. This domain may form a binding site for IP3 [PMID: 10664581].

GO terms

Biological Process

GO:0070588 calcium ion transmembrane transport

Molecular Function

GO:0005262 calcium channel activity

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.