Conserved Site

ATP-dependent RNA helicase DEAD-box, conserved site (IPR000629)

Short name: RNA-helicase_DEAD-box_CS


A number of eukaryotic and prokaryotic proteins involved in ATP-dependent, nucleic-acid unwinding have been characterised [PMID: 1552844, PMID: 2563148, PMID: 1825133] on the basis of their structural similarity. All these proteins share a number of conserved sequence motifs. Some of them are specific to this family while others are shared by other ATP-binding proteins or by proteins belonging to the helicases `superfamily'. One of these motifs, called the 'D-E-A-D-box', represents a special version of the B motif of ATP-binding proteins. Proteins currently known to belong to this family include eukaryotic initiation factor eIF-4A; yeast PRP5, PRP28 and MSS116 splicing proteins, and proteins DHH1, DRS1, MAK5 and ROK1; mouse Pl10, Caenorhabditis elegans helicase glh-1; Drosophila Rm62 (p62), Me31B and Vasa; and Escherichia coli putative RNA helicases dbpA, deaD, rhlB and rhlE.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns