ROK family (IPR000600)

Short name: ROK

Overlapping homologous superfamilies


Family relationships


A family of bacterial proteins has been described which groups transcriptional repressors, sugar kinases and yet uncharacterised open reading frames [PMID: 7952186]. This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase EC: from Streptomyces coelicolor; fructokinase EC: from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase EC: and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE patterns