Frizzled/Smoothened, transmembrane domain (IPR000539)

Short name: Frizzled/Smoothened_TM

Overlapping homologous superfamilies


Domain relationships


This domain is the membrane spanning region of frizzled and smoothened receptors. This membrane region is predicted to contain seven transmembrane alpha helices. Proteins related to Drosophila frizzled (P18537) are receptors for Wnt (mediating the beta-catenin signalling pathway) [PMID: 8717036], but also the planar cell polarity (PCP) pathway and the Wnt/calcium pathway. The predominantly alpha-helical Cys-rich ligand-binding region (CRD) of Frizzled is both necessary and sufficient for Wnt binding [PMID: 15239825]. The smoothened receptor mediates hedgehog signalling [PMID: 9811578].

GO terms

Biological Process

GO:0007166 cell surface receptor signaling pathway

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016020 membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.