Large envelope protein S (IPR000349)

Short name: HBV_HBSAG

Overlapping homologous superfamilies


Family relationships



This entry represents the large envelope protein S from hepatitis B virus. The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein [PMID: 9498079, PMID: 15567498, PMID: 16863502].

GO terms

Biological Process

GO:0016032 viral process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.