Rap GTPase activating protein domain (IPR000331)

Short name: Rap_GAP_dom

Overlapping homologous superfamilies

Domain relationships



Rap small G proteins have been implicated in various cellular processes such as exocytosis, cAMP signalling, cell adhesion and cell proliferation. Rap proteins acts as molecular switches, with an active GTP-bound form and an inactive GDP-bound form [PMID: 11331911]. The inactive GDP bound form is promoted by GTPase-activating proteins (GAPs). GAP proteins specific for Rap contain a conserved region of around 200 amino-acid residues, the RapGAP domain. This domain can accelerate the GTP hydrolysis activity of Rap by five orders of magnitude [PMID: 9346962].

Proteins known to contain a Rap-GAP domain include:

  • RAP1 GTPase activating protein (RAP1GAP).
  • Mammalian tuberin protein, the product of a familial tuberous sclerosis gene which, when deleted, causes begnin tumours. It also have a GAP activity for Rab5 [PMID: 9045618].
  • Drosophila Gigas protein, an homologue of tuberin involved in regulation of cell cycle.
  • Mammalian tuberin-like protein TULIP.
  • GTPase-activating protein Spa-1. It functions as a negative regulator for the activation of Rap1, thereby having a negative effect on cell adhesion [PMID: 10373454].

GO terms

Biological Process

GO:0051056 regulation of small GTPase mediated signal transduction

Molecular Function

GO:0005096 GTPase activator activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles