Rho GTPase-activating protein domain (IPR000198)

Short name: RhoGAP_dom

Overlapping homologous superfamilies

Domain relationships


Members of the Rho family of small G proteins transduce signals from plasma-membrane receptors and control cell adhesion, motility and shape by actin cytoskeleton formation. Like all other GTPases, Rho proteins act as molecular switches, with an active GTP-bound form and an inactive GDP-bound form. The active conformation is promoted by guanine-nucleotide exchange factors, and the inactive state by GTPase-activating proteins (GAPs) which stimulate the intrinsic GTPase activity of small G proteins. This entry is a Rho/Rac/Cdc42-like GAP domain, that is found in a wide variety of large, multi-functional proteins [PMID: 9009196]. A number of structure are known for this family [PMID: 9009196, PMID: 8962058, PMID: 9262406]. The domain is composed of seven alpha helices. This domain is also known as the breakpoint cluster region-homology (BH) domain.

GO terms

Biological Process

GO:0007165 signal transduction

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles