Ornithine/DAP/Arg decarboxylase (IPR000183)

Short name: Orn/DAP/Arg_de-COase

Overlapping homologous superfamilies

Family relationships


Pyridoxal-dependent decarboxylases acting on ornithine, lysine, arginine and related substrates can be classified into two different families on the basis of sequence similarities [PMID: 3143046, PMID: 8181483]. Members of this family while most probably evolutionary related, do not share extensive regions of sequence similarities. The proteins contain a conserved lysine residue which is known, in mouse ODC [PMID: 1730582], to be the site of attachment of the pyridoxal-phosphate group. The proteins also contain a stretch of three consecutive glycine residues and has been proposed to be part of a substrate-binding region [PMID: 2198270].

These enzymes are collectively known as group IV decarboxylases, and include ornithine and arginine decarboxylases, and diaminopimelate decarboxylase (DAP) [PMID: 8181483].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003824 catalytic activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.